| Superfamily | Functional Family | Mutation Events | Mutation Types | DOPS | Incl. Bitscore | Incl. Evalue | Seqs |
|---|---|---|---|---|---|---|---|
| 3.40.50.620 | Probable NH(3)-dependent NAD(+) synthetase
3.40.50.620-FF-89155
|
4
|
BRCA (2)
LUAD (2)
|
90.1 | 105.3 | 1.0E-30 | 4554 |
| 3.40.50.620 | Probable tyrosine--tRNA ligase, mitochondrial
3.40.50.620-FF-88792
|
10
|
CESC (2)
KIRC (2)
LUAD (4)
ESCA (2)
|
95.3 | 124.8 | 1.5E-36 | 1812 |
| 3.40.309.10 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
3.40.309.10-FF-17520
|
14
|
PRAD (2)
UCEC (2)
LUSC (2)
LUAD (2)
COAD (4)
STAD (2)
|
90.3 | 246.3 | 3.0E-74 | 3147 |
| 3.40.309.10 | Probable succinate-semialdehyde dehydrogenase [NADP(+)]
3.40.309.10-FF-17539
|
2
|
UCEC (2)
|
91.6 | 221.2 | 1.8E-66 | 3797 |
| 3.40.640.10 | Glycine dehydrogenase (decarboxylating), mitochondrial
3.40.640.10-FF-62877
|
2
|
COAD (2)
|
92.3 | 226.4 | 8.4E-68 | 2843 |
| 3.40.50.620 | tRNA-specific 2-thiouridylase MnmA 1
3.40.50.620-FF-88849
|
4
|
BLCA (2)
SKCM (2)
|
93.8 | 184.8 | 5.4E-55 | 9341 |
| 3.40.640.10 | Serine--pyruvate aminotransferase, mitochondrial
3.40.640.10-FF-62953
|
4
|
SKCM (4)
|
92.1 | 249.3 | 1.1E-75 | 1160 |
| 3.40.640.10 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial
3.40.640.10-FF-63070
|
2
|
UCEC (2)
|
96.2 | 270.4 | 7.6E-82 | 1313 |
| 3.40.640.10 | Cysteine desulfurase IscS, mitochondrial
3.40.640.10-FF-63415
|
4
|
LUSC (2)
UCEC (2)
|
94.5 | 117.8 | 3.8E-34 | 9084 |
| 3.40.640.10 | Kynureninase (L-kynurenine hydrolase) variant
3.40.640.10-FF-63117
|
14
|
SKCM (8)
UCEC (4)
GBM (2)
|
91.6 | 300.6 | 3.7E-91 | 1141 |
| 2.30.30.140 | Lethal(3)malignant brain tumor-like protein 2
2.30.30.140-FF-3041
|
10
|
UCEC (4)
SKCM (4)
PAAD (2)
|
84.4 | 153.0 | 2.9E-47 | 305 |
| 3.60.90.10 | S-adenosylmethionine decarboxylase proenzyme 1
3.60.90.10-FF-1097
|
8
|
UCEC (4)
GBM (2)
COAD (2)
|
93.8 | 188.1 | 8.2E-57 | 1680 |
| 2.120.10.80 | Kelch-like protein 12
2.120.10.80-FF-8779
|
16
|
SKCM (4)
UCEC (4)
STAD (4)
COAD (2)
HNSC (2)
|
71.5 | 325.6 | 2.2E-101 | 124 |
| 3.90.530.10 | DNA repair protein-complementing XP-A cells
3.90.530.10-FF-202
|
4
|
UCEC (4)
|
82.7 | 168.9 | 1.6E-52 | 145 |
| 2.30.30.140 | Histone-lysine N-methyltransferase NSD3
2.30.30.140-FF-3063
|
6
|
LIHC (4)
SKCM (2)
|
88.6 | 144.7 | 1.8E-44 | 399 |
| 2.30.30.140 | Scm-like with four mbt domains 1
2.30.30.140-FF-3074
|
2
|
UCEC (2)
|
96.0 | 146.4 | 1.4E-44 | 538 |
| 2.30.30.40 | Dynamin-binding protein
2.30.30.40-FF-19043
|
2
|
LUSC (2)
|
70.9 | 175.3 | 7.8E-55 | 88 |
| 2.30.30.140 | Survival motor neuron protein
2.30.30.140-FF-4819
|
2
|
UCEC (2)
|
91.8 | 104.2 | 9.5E-33 | 550 |
| 3.40.50.10380 | NAD-dependent malic enzyme, mitochondrial
3.40.50.10380-FF-1964
|
2
|
SKCM (2)
|
94.7 | 219.4 | 6.2E-66 | 7468 |
| 2.30.30.40 | Abl interactor 2
2.30.30.40-FF-19254
|
2
|
UCEC (2)
|
73.6 | 135.0 | 4.2E-42 | 456 |