| Superfamily | Functional Family | Mutation Events | Mutation Types | DOPS | Incl. Bitscore | Incl. Evalue | Seqs |
|---|---|---|---|---|---|---|---|
| 2.60.200.20 | E3 ubiquitin-protein ligase RNF8
2.60.200.20-FF-8161
|
4
|
LGG (2)
BLCA (2)
|
88.8 | 156.0 | 2.4E-48 | 106 |
| 2.60.200.20 | Kinesin-like protein unc-104
2.60.200.20-FF-8178
|
8
|
LUAD (2)
UCEC (4)
SKCM (2)
|
82.6 | 131.5 | 5.0E-40 | 854 |
| 3.40.449.10 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
3.40.449.10-FF-1486
|
16
|
BLCA (2)
COAD (2)
SKCM (12)
|
93.9 | 197.7 | 1.3E-59 | 1951 |
| 3.40.630.10 | Glutaminyl-peptide cyclotransferase (Glutaminyl cyclase)
3.40.630.10-FF-34591
|
2
|
STAD (2)
|
89.9 | 359.3 | 1.9E-109 | 291 |
| 3.40.630.10 | Glutamate carboxypeptidase 2 homolog
3.40.630.10-FF-34828
|
2
|
SKCM (2)
|
93.9 | 159.3 | 1.3E-47 | 1019 |
| 2.30.130.10 | 60S ribosome subunit biogenesis protein
2.30.130.10-FF-4587
|
2
|
UCEC (2)
|
96.0 | 139.8 | 4.6E-43 | 1079 |
| 3.30.540.10 | Uncharacterised protein
3.30.540.10-FF-6473
|
6
|
UCEC (2)
PRAD (2)
STAD (2)
|
83.0 | 221.3 | 3.7E-68 | 128 |
| 3.30.800.10 | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
3.30.800.10-FF-688
|
6
|
BLCA (2)
CESC (4)
|
83.0 | 243.5 | 2.1E-74 | 855 |
| 3.90.470.10 | 39S ribosomal protein L22, mitochondrial
3.90.470.10-FF-1953
|
6
|
UCEC (4)
CESC (2)
|
85.9 | 240.6 | 4.3E-74 | 112 |
| 2.170.300.10 | Tyrosine-protein kinase receptor Tie-1
2.170.300.10-FF-7750
|
2
|
SKCM (2)
|
80.8 | 169.9 | 3.1E-52 | 175 |
| 2.30.250.10 | Probable M18 family aminopeptidase 2
2.30.250.10-FF-811
|
2
|
GBM (2)
|
94.5 | 106.6 | 2.1E-32 | 2146 |
| 2.40.70.10 | Beta-site APP-cleaving enzyme 1
2.40.70.10-FF-22817
|
20
|
LIHC (2)
UCEC (4)
STAD (2)
PRAD (4)
SKCM (4)
COAD (2)
LUAD (2)
|
80.0 | 373.0 | 4.3E-114 | 172 |
| 2.40.70.10 | Beta-site APP-cleaving enzyme 1
2.40.70.10-FF-22859
|
4
|
UCEC (4)
|
78.5 | 202.4 | 9.6E-63 | 98 |
| 2.40.70.10 | Cathepsin D (A01 family)
2.40.70.10-FF-23002
|
6
|
GBM (2)
UCEC (2)
LUAD (2)
|
87.2 | 142.9 | 9.0E-44 | 362 |
| 2.60.40.150 | Small nuclear ribonucleoprotein 200kDa
2.60.40.150-FF-15495
|
2
|
UCEC (2)
|
88.7 | 133.5 | 3.9E-41 | 388 |
| 2.60.40.150 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
2.60.40.150-FF-15597
|
108
|
BLCA (4)
BRCA (38)
SARC (2)
STAD (16)
UCEC (18)
GBM (2)
TGCT (2)
HNSC (6)
COAD (8)
LGG (4)
LUAD (2)
PRAD (2)
UCS (2)
CESC (2)
|
87.7 | 115.0 | 1.6E-35 | 229 |
| 3.30.870.10 | Mitochondrial cardiolipin hydrolase
3.30.870.10-FF-12790
|
14
|
STAD (2)
DLBC (2)
BLCA (2)
KIRP (2)
CESC (2)
UCEC (4)
|
93.2 | 232.1 | 9.3E-72 | 52 |
| 3.30.870.10 | Tyrosyl-DNA phosphodiesterase 1
3.30.870.10-FF-12826
|
2
|
LUSC (2)
|
91.6 | 171.5 | 1.1E-52 | 174 |
| 1.10.10.10 | DEP domain-containing protein 1A
1.10.10.10-FF-263040
|
2
|
HNSC (2)
|
93.4 | 151.6 | 1.8E-47 | 201 |
| 1.10.10.10 | Segment polarity protein dishevelled
1.10.10.10-FF-263989
|
6
|
LUAD (4)
UCEC (2)
|
90.2 | 133.5 | 3.8E-41 | 590 |