| Superfamily | Functional Family | Mutation Events | Mutation Types | DOPS | Incl. Bitscore | Incl. Evalue | Seqs |
|---|---|---|---|---|---|---|---|
| 2.60.200.20 | Mediator of DNA damage checkpoint protein 1
2.60.200.20-FF-8126
|
2
|
UCEC (2)
|
77.1 | 183.9 | 2.4E-57 | 47 |
| 2.60.200.20 | Centrosomal protein of 170 kDa
2.60.200.20-FF-8129
|
8
|
STAD (2)
UCEC (4)
READ (2)
|
77.1 | 156.1 | 4.3E-48 | 256 |
| 2.60.200.20 | E3 ubiquitin-protein ligase RNF8
2.60.200.20-FF-8161
|
4
|
LGG (2)
BLCA (2)
|
88.8 | 156.0 | 2.4E-48 | 106 |
| 2.60.200.20 | Kinesin-like protein unc-104
2.60.200.20-FF-8178
|
8
|
LUAD (2)
UCEC (4)
SKCM (2)
|
82.6 | 131.5 | 5.0E-40 | 854 |
| 3.40.630.10 | Aminoacylase-1
3.40.630.10-FF-34417
|
6
|
BRCA (2)
COAD (2)
BLCA (2)
|
89.8 | 274.9 | 3.3E-84 | 238 |
| 3.60.20.10 | Proteasome subunit beta type
3.60.20.10-FF-15794
|
2
|
LUSC (2)
|
90.6 | 271.7 | 5.8E-83 | 500 |
| 3.60.20.10 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
3.60.20.10-FF-15819
|
8
|
STAD (2)
GBM (2)
UCEC (4)
|
88.7 | 197.4 | 8.8E-59 | 1971 |
| 3.90.1110.10 | RNA polymerase II subunit
3.90.1110.10-FF-1871
|
4
|
DLBC (2)
UCEC (2)
|
89.9 | 220.3 | 6.6E-67 | 1605 |
| 3.90.1110.10 | DNA-directed RNA polymerase
3.90.1110.10-FF-1889
|
16
|
UCEC (8)
COAD (2)
LUAD (2)
BRCA (2)
UCS (2)
|
92.0 | 193.7 | 5.5E-59 | 855 |
| 1.20.1110.10 | Calcium-transporting ATPase, endoplasmic reticulum-type
1.20.1110.10-FF-14619
|
8
|
SKCM (6)
BLCA (2)
|
87.9 | 344.7 | 2.7E-104 | 1009 |
| 1.20.1110.10 | Sodium/potassium-transporting ATPase alpha subunit
1.20.1110.10-FF-14688
|
2
|
UCEC (2)
|
96.9 | 283.5 | 1.6E-86 | 999 |
| 1.20.140.20 | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
1.20.140.20-FF-398
|
10
|
CESC (2)
UCEC (4)
LUAD (2)
GBM (2)
|
73.7 | 250.3 | 2.4E-77 | 88 |
| 2.30.39.10 | Glia-derived nexin
2.30.39.10-FF-4309
|
6
|
COAD (2)
SKCM (2)
UCEC (2)
|
71.0 | 219.8 | 6.5E-69 | 108 |
| 2.30.39.10 | Thyroxine-binding globulin
2.30.39.10-FF-4375
|
16
|
SARC (2)
COAD (4)
SKCM (6)
PAAD (2)
UCEC (2)
|
85.0 | 157.7 | 1.0E-49 | 63 |
| 2.30.39.10 | Alpha-1 antitrypsin
2.30.39.10-FF-4434
|
4
|
STAD (2)
HNSC (2)
|
76.6 | 149.3 | 7.4E-47 | 81 |
| 3.20.20.100 | Aflatoxin B1 aldehyde reductase member 2
3.20.20.100-FF-14931
|
14
|
BLCA (2)
UCEC (4)
STAD (4)
COAD (2)
SKCM (2)
|
77.3 | 586.2 | 4.4E-179 | 60 |
| 3.20.20.100 | Voltage-gated potassium channel beta subunit
3.20.20.100-FF-15013
|
12
|
COAD (4)
HNSC (2)
UCEC (4)
CESC (2)
|
81.6 | 306.2 | 8.5E-93 | 1365 |
| 3.20.20.330 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase)
3.20.20.330-FF-1374
|
6
|
LUSC (2)
SKCM (4)
|
92.7 | 296.3 | 3.1E-89 | 2744 |
| 3.40.50.1240 | Ubiquitin-associated and SH3 domain-containing protein B
3.40.50.1240-FF-13397
|
26
|
CHOL (2)
GBM (2)
SKCM (10)
UCEC (6)
BRCA (2)
MESO (2)
LUSC (2)
|
81.6 | 174.1 | 6.3E-53 | 506 |
| 3.60.10.10 | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
3.60.10.10-FF-13379
|
2
|
KIRP (2)
|
87.5 | 537.8 | 7.8E-164 | 208 |